About the lab

We are a newly established computational research group at the Translational Genomics Research Institute developing and applying pangenome methods to study genome variation and evolution. Our work builds on experience developing pangenome graph construction and analysis tools (PGGB, ODGI, IMPG) and contributions to the Telomere-to-Telomere Consortium and Human Pangenome Reference Consortium.

We use long-read sequencing and de novo genome assembly to construct personalized pangenomes for cancer samples, detecting somatic structural variation that reference-based methods miss. We also aim to reduce the cost and complexity of germline genome assembly to make personalized pangenomics more routine in clinical and research settings. Additionally, we are developing pangenome-based approaches for genome-wide association studies.

We are looking for a passionate and highly motivated postdoctoral fellow to join our team.

Position summary

The postdoctoral fellow will develop and apply computational methods for cancer pangenomics using long-read sequencing data. Through our collaboration with the Barthel Lab, we have access to in-house PacBio Revio and Oxford Nanopore PromethION platforms with skilled library preparation support, ensuring ample data. The candidate will also be encouraged to identify and pursue new research areas and ideas.

This position offers flexibility: hybrid or fully remote arrangements are possible for the right candidate.

Responsibilities

• Developing computational tools for analyzing and visualizing long-read sequencing data and genome assemblies in normal and tumor samples
• Constructing personalized pangenomes to characterize somatic structural variation
• Contributing to pangenome-based variant calling and association study pipelines
• Working with large-scale genomic, epigenomic, and transcriptomic data
• Contributing to genome assembly and comparative genomics analyses
• Collaborating with internal and external partners, including consortium colleagues (e.g., Telomere-to-Telomere Consortium, Human Pangenome Reference Consortium)
• Building and maintaining reproducible workflows (e.g., Snakemake, Nextflow)
• Presenting research internally and externally (e.g., conferences)