Join the transformative team at City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and treatment facilities in Atlanta, Chicago and Phoenix. Our dedicated and compassionate employees are driven by a common mission: To deliver the cures of tomorrow to the people who need them today. 

Are you a compassionate and detail-oriented Registered Nurse passionate about advancing healthcare? Join our team as a Clinical Research Nurse, where you’ll play a vital role in guiding patients through innovative clinical trials while collaborating with a multidisciplinary team of physicians, Clinical Research Associates (CRA), pharmacists, and coordinators.

This is a unique opportunity to blend clinical expertise with research excellence—helping bring groundbreaking treatments to life while delivering exceptional patient-centered care.

What You’ll Do

Clinical Trial Patient Management

• Partner with investigators to determine patient eligibility and ensure accurate documentation of clinical trial criteria
• Assess, monitor, and document patient conditions, treatment responses, and changes in health status in accordance with IRB protocols
• Coordinate care across the continuum (outpatient, inpatient, and home settings)
• Triage patient calls and provide proactive communication and support to patients and families
• Collaborate closely with physicians, nurse practitioners (NPs), physician assistants (PAs), pharmacists, and research teams
• Plan and execute protocol-specific activities including randomization, assessments, treatments, and follow-ups
• Ensure all clinical trial documentation is complete, accurate, and compliant to avoid protocol deviations

• Support and monitor patient adherence to study protocols

Patient & Family Education

• Educate patients and families on clinical trial treatments, procedures, and follow-up care
• Provide ongoing support to ensure understanding and adherence to treatment plans

Informed Consent & Compliance

• Ensure informed consent processes meet all regulatory requirements (IRB, FDA, institutional, and sponsor guidelines)
• Participate in patient education during consent and escalate concerns to the Principal Investigator
• Maintain timely and accurate documentation of consent forms

Protocol Oversight & Collaboration

• Assist with study initiation, monitoring visits, and audits
• Collaborate with research pharmacy and investigators to develop and implement protocol-specific orders
• Promote adherence to clinical trial protocols and regulatory standards
• Coordinate scheduling of patient visits, testing, and follow-ups
• Educate nursing staff on protocol requirements and safe medication administration

Additional Responsibilities

• Deliver patient-centered care in alignment with organizational policies and the California Nurse Practice Act
• Maintain a high standard of professionalism, teamwork, and organization
• Stay current with clinical research regulations, standards, and best practices
• Serve as a mentor or preceptor for new staff and nursing students
• Collaborate with internal teams and external partners including physicians, sponsors, and community resources
• Full time 10 hour days / 40 hour week

Your qualifications should include: 

• BSN
• 2 or more years of experience in oncology. clinical research, research, ICU, other intensive care setting, pediatrics, case management or nurse navigation.
• Human subjects protection training (can be completed after hire)

Required Certification/Licensure:

• Current California RN License
• American Heart Association BLS Certification

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

To learn more about our Comprehensive Benefits, please CLICK HERE.