City of Hope Orange County is transforming cancer treatment by bringing world-class expertise and specialized care closer to home. Supported by a regional network of care, our 11-acre academic cancer campus in Irvine is home to City of Hope Orange County Lennar Foundation Cancer Center, our outpatient cancer center, and Orange County’s only cancer specialty hospital, opening in late 2025.

With the opening of the hospital, the full continuum of advanced cancer care—from prevention through survivorship—will be available in Orange County for the first time, eliminating the need to travel for lifesaving treatment. Seamlessly connected to our outpatient cancer center, the new clinical research hospital will feature 73 inpatient beds, advanced surgical suites, groundbreaking clinical trials, and holistic services such as rehabilitative therapy and spiritual care. This isn’t standard cancer care. This is lifesaving cancer care. This is Hope.

Position Summary

City of Hope is seeking a skilled and compassionate Clinical Nurse to join our exceptional team in the operating room, specializing in cancer treatment. In this crucial role, you will contribute to the fight against cancer by providing outstanding surgical care to our patients. The OR Nurse prepares patients for surgery, assists during operations, and ensures a sterile and safe environment. The OR Nurse will collaborate closely with surgeons, anesthesiologists, and other healthcare professionals to deliver exceptional care tailored to the unique needs of oncology patients. This opportunity is for full time, 12-hour shifts (3 shifts per week). Call is a requirement for this position. 

Up to $20,000 Sign-on Bonus Available!

As a successful candidate, you will: 

• Assist in surgical procedures related to cancer treatment, including tumor removal, organ resection, and reconstructive surgery. 
• Ensure the operating room is prepared with the necessary equipment, instruments, and supplies for each procedure.
• Prepare the operating room for procedures, including any necessary supplies, medications, and/or equipment, following aseptic and evidence-based practices. 
• Learn and maintain competencies for innovative surgical technology including robotic-assisted surgery. 
• Care and advocate for patients throughout the surgical care journey. 
• Maintain meticulous documentation of surgical procedures. 

Your qualifications should include: 

• Bachelor’s Degree or Master’s degree in Nursing is required 
• Current California RN license.
• Minimum of three (3) years related experience as a RN.
• Requirement of 1-year perioperative experience or a formal Perioperative nursing specialty course completed prior to application or within 6 months of hire or transfer.
• Basic Life Support (BLS) through American Heart Association
• ACLS through American Heart Association
• CNOR (preferred)

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

To learn more about our Comprehensive Benefits, please CLICK HERE.