City of Hope Orange County is transforming cancer treatment by bringing world-class expertise and specialized care closer to home. Supported by a regional network of care, our 11-acre academic cancer campus in Irvine is home to City of Hope Orange County Lennar Foundation Cancer Center, our outpatient cancer center, and Orange County’s only cancer specialty hospital, opening in late 2025.

With the opening of the hospital, the full continuum of advanced cancer care—from prevention through survivorship—will be available in Orange County for the first time, eliminating the need to travel for lifesaving treatment. Seamlessly connected to our outpatient cancer center, the new clinical research hospital will feature 73 inpatient beds, advanced surgical suites, groundbreaking clinical trials, and holistic services such as rehabilitative therapy and spiritual care. This isn’t standard cancer care. This is lifesaving cancer care. This is Hope.

We are seeking experienced nurses for our 8-bed Evaluation and Treatment Center (ETC) at City of Hope Orange County Cancer Specialty Hospital as a Clinical Nurse III in the ETC you will provide compassionate care to our oncology patients who are requiring urgent evaluation and intervention.  This role is vital in addressing acute symptoms related to cancer, treatment side effects, and oncologic emergencies. 

The Clinical Nurse III performs rapid assessments, triage, and stabilization with strong understanding of oncology pathophysiology and the unique needs of immunocompromised patients.  You will collaborate closely with physicians, and the interdisciplinary care team, the Clinical Nurse ensure timely, individualized care that prioritizes both safety and the dignity of the patient.

The position requires clinical expertise, strong critical thinking, emotional resilience, and a deep commitment to supporting patents and families.

As a successful candidate, you will: 

• Utilizes the nursing process and practice standards as a framework for the management of patient care.
• Can assess patient conditions, recognize early signs of complications, escalation of care when necessary, and continuity of care through coordination with inpatient, outpatient, and palliative teams.
• Administering specialized medications, monitoring treatment responses, managing central lines and infusion devices.
• Demonstrates knowledge of the clinical information system and applies principles to patient documentation.
• Prioritizes holistic care, addressing both the physical and emotional needs of the patients.
• Serves as a mentor and role model to new staff members.
• Delegates to licensed and unlicensed personnel.
• Integrates and practices according to the City of Hope Professional Practice Model to deliver care service excellence.  
• In alignment with City of Hope mission and values, the Division of Nursing and Patient Care Services vision and mission, and with continuous focus on the patient, family and community, carries out the nursing process, coordinates interdisciplinary care planning, documents according to standards, including validation of the patient and caregiver’s understanding of the plan of care and expected outcomes.
• The nurse is a change agent, committed to lifelong learning, professional development and embodiment of City of Hope organizational mission and values, and the values and ethos of the profession of nursing.
• Sign On Bonus: $20,000
• Shift: Days
• This position is also eligible for a night shift differential up to $6.50/hr and weekend differential up to $15.60/hr.   
• Multiple Positions Available

Your qualifications should include: 

• Bachelor’s Degree 
• One – two years related experience or after successful completion of role of CN I (typically for 12 months) Urgent care and/or ER experience
• Current CA Registered Nurse License
• Current Basic Life Support (BLS) through American Heart Association
• Current Advanced Cardiac Life Support (ACLS) through American Heart Association

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.  To learn more about our Comprehensive Benefits, please CLICK HERE.