City of Hope Orange County is transforming cancer treatment by bringing world-class expertise and specialized care closer to home. Supported by a regional network of care, our 11-acre academic cancer campus in Irvine is home to City of Hope Orange County Lennar Foundation Cancer Center, our outpatient cancer center, and Orange County’s only cancer specialty hospital, opening in late 2025.

With the opening of the hospital, the full continuum of advanced cancer care—from prevention through survivorship—will be available in Orange County for the first time, eliminating the need to travel for lifesaving treatment. Seamlessly connected to our outpatient cancer center, the new clinical research hospital will feature 73 inpatient beds, advanced surgical suites, groundbreaking clinical trials, and holistic services such as rehabilitative therapy and spiritual care. This isn’t standard cancer care. This is lifesaving cancer care. This is Hope.

We are seeking an Evaluation Treatment Center (ETC)/Urgent Care Nurse Manager for City of Hope Orange County Cancer Specialty Hospital where you will play a pivotal role in leading and managing the operations of a high-acuity, fast-paced 8 bed-unit that provides urgent and emergent care to our patients. This unit serves as a critical access point for patients experiencing complications related to their cancer treatment, disease progression, or other acute health concerns.

The Nurse Manager ensures safe, compassionate, and efficient nursing care for immunocompromised and medically complex patients, often presenting with oncologic emergencies such as febrile neutropenia, sepsis, pain crises, or treatment-related side effects. This role requires a strong clinical background in oncology and/or emergency care, paired with outstanding leadership and operational management capabilities.

In collaboration with oncologists, and interdisciplinary teams, the Nurse Manager promotes evidence-based practice, optimizes patient flow, and maintains a therapeutic and supportive environment. The Nurse Manager also ensures compliance with institutional, state, and federal standards, while fostering staff development and patient-centered care.

As a successful candidate, you will:

• Direct, supervise, and support nursing and clinical support staff in the ETC/Urgent Care unit for oncology patients.
• Coordinate 24/7 clinical operations to ensure timely triage, evaluation, and treatment of acutely ill cancer patients.
• Oversee staffing, scheduling, and resource allocation to maintain optimal patient-to-staff ratios and high standards of care.
• Implement and monitor quality improvement initiatives targeting oncology-specific metrics such as infection control, pain management, and treatment timeliness.
• Ensure compliance with regulatory standards (e.g., Joint Commission, CMS, Oncology Nursing Society guidelines).
• Collaborate with hospital leadership and the cancer care team to develop protocols for managing oncologic emergencies.
• Support professional development, certification, and continuing education for staff in oncology and emergency care.
• Promote a culture of safety, compassion, and excellence in care delivery for patients and families navigating cancer treatment.

Your qualifications should include:

• Bachelor’s degree or master’s degree in nursing is required. 
• 3 years of experience in an area of expertise relevant to the department with demonstrated progressive leadership growth.
• Current California Registered Nurse license
• Current BLS from the American Heart Association
• National Certification (must be acquired within 12 months of hire or transfer) OCN or BMTCN preferred.

City of Hope employees’ pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer.  To learn more about our Comprehensive Benefits, please CLICK HERE.