City of Hope Orange County is transforming cancer treatment by bringing world-class expertise and specialized care closer to home. Supported by a regional network of care, our 11-acre academic cancer campus in Irvine is home to City of Hope Orange County Lennar Foundation Cancer Center, our outpatient cancer center, and Orange County’s only cancer specialty hospital, opening in late 2025.

With the opening of the hospital, the full continuum of advanced cancer care—from prevention through survivorship—will be available in Orange County for the first time, eliminating the need to travel for lifesaving treatment. Seamlessly connected to our outpatient cancer center, the new clinical research hospital will feature 73 inpatient beds, advanced surgical suites, groundbreaking clinical trials, and holistic services such as rehabilitative therapy and spiritual care. This isn’t standard cancer care. This is lifesaving cancer care. This is Hope.

Position Summary

Are you an experienced Medical Surgical nurse looking for an opportunity to make a real difference in the lives of cancer patients?  Join our team at City of Hope Orange County Cancer Specialty Hospital as a Clinical Nurse III in the Medical Surgical Unit and be part of a groundbreaking team dedicated to providing world-class, compassionate care to a diverse range of patients including those with cardiac, respiratory, sepsis, diabetes and general surgery conditions. 

As a Clinical Nurse III, you will play a vital role in guiding and coordinating care for patients in the Medical Surgical unit, ensuring the highest standards of treatment in accordance with our Nursing Department’s policies and procedures.  From comprehensive patient assessments and personalized care planning to implementing treatment plans and collaborating with interdisciplinary teams, your expertise will directly impact patient outcomes. 

We are looking for passionate, skilled nurses who can think critically, act decisively, and provide compassionate support to patients and families.  Your ability to effectively communicate, document, and integrate cultural, psychosocial, and spiritual needs into care plans will be key to delivering exceptional care.

Up to $20,000 Sign-on Bonus Available!

 As a successful candidate, you will: 

• Patient Assessment and Monitoring: Nurses in the Hematology unit conduct thorough assessments of patients with hematologic malignancies, including physical exams, review of medical history, and assessment of symptoms such as fatigue, bruising, and bleeding. They monitor vital signs, laboratory results, and response to treatment to detect any changes in patient status.
• Chemotherapy Administration: Nurses are responsible for administering chemotherapy and other systemic treatments according to established protocols and guidelines. They ensure accurate dosing, monitor for potential side effects, and provide supportive care to minimize treatment-related complications.
• Symptom Management: Nurses assess and manage symptoms associated with hematologic malignancies and their treatments, such as pain, nausea, anemia, and neutropenia. They administer medications, provide comfort measures, and educate patients on self-care techniques to improve symptom control and quality of life.
• Patient Education: Nurses play a crucial role in educating patients and their families about their diagnosis, treatment options, and potential side effects. They provide information on managing treatment-related symptoms, adhering to medication regimens, and accessing support services such as counseling, nutrition therapy, and financial assistance.
• Care Coordination: Nurses collaborate with the multidisciplinary team to develop and implement individualized care plans for patients with hematologic malignancies. They coordinate appointments, diagnostic tests, and consultations with specialists, ensuring seamless continuity of care throughout the treatment process.

Your qualifications should include:

• Bachelor’s Degree or Master’s degree in Nursing is required
• Current California RN license
• Minimum of three (3) years related experience
• Basic Life Support (BLS) CPR Card through American Heart Association
• Preferred experience - Oncology, Hematology, Intensive Care (ICU), Step Down (SDU), MedSurg

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

To learn more about our Comprehensive Benefits, please click here